Medical Epidemiology
Our main research concern diseases and conditions in the ageing population, including fragility fractures, cardiovascular diseases and cancer, but we are involved in other areas of epidemiological research as well.
The Medical Epidemiology research group is based at the EpiHub (map), an office and network for epidemiological research within the the Disciplinary domain of Medicine and Pharmacy at Uppsala University. This facilitates fruitful interaction with different research groups aiming to jointly build a long term foundation for advanced epidemiological research.
Our main research concern diseases and conditions in the ageing population, including fragility fractures, cardiovascular diseases and cancer, but we are involved in other areas of epidemiological research as well. We combine traditional epidemiological methods with modern causal inference methods in observational studies and perform randomised intervention studies. Find out more about our research by browsing through our publication list.
SIMPLER
Karl Michaëlsson, head of Medical Epidemiology, is also director for the national research infrastructure SIMPLER, Swedish Infrastructure for Medical Population-Based Life-Course and Environmental Research (simpler4health.se) and much of our research is based on the cohorts included in SIMPLER. Since the end of 2018 the infrastructure is managed by a consortium consisting of Uppsala University, Karolinska Institutet, Chalmers University of Technology and Örebro University in collaboration with the County Councils in Uppsala, Västmanland and Örebro County.
The infrastructure's mission is to provide national and international researchers with data for studies on how dietary and lifestyle factors and genetics affect our health, especially during the latter part of life. The knowledge can for example be used to develop recommendations on diet and lifestyle, develop new markers fore easier and more accurate diagnosis of chronic diseases and their precursors and to develop new individualized treatments.
Funding
The research group has received funding from the Swedish Research Council (VR), the Swedish Research Council for Health, Working Life and Welfare (FORTE), the Swedish Heart-Lung Foundation, the Swedish Cancer Society, Hjärnfonden, and ALF.
Publications
Part of Environmental Science and Technology, p. 1036-1047, 2024
Markers of imminent myocardial infarction
Part of Nature Cardiovascular Research, 2024
Part of Cell Death Discovery, 2024
Part of Journal of Autoimmunity, 2024
Part of Cancer Causes and Control, p. 367-376, 2024
Part of The Journal of Nutrition, Health & Aging, p. 100247-100247, 2024
Part of European Journal of Nutrition, 2024
Digestive System Diseases, Genetic Risk, and Incident Dementia: A Prospective Cohort Study
Part of American Journal of Preventive Medicine, p. 516-525, 2024
Part of BMC Medicine, 2024
- DOI for Genetic investigation into the broad health implications of caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization
- Download full text (pdf) of Genetic investigation into the broad health implications of caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization
Part of EBioMedicine, 2024
Design, Methods, and Participation in Riksmaten Young Children—A Swedish National Dietary Survey
Part of Current Developments in Nutrition, p. 102150-102150, 2024
Part of Nutrition (Burbank, Los Angeles County, Calif.), 2023
Inverse Association Between Serum 25-Hydroxyvitamin D and Nonalcoholic Fatty Liver Disease
Part of Clinical Gastroenterology and Hepatology, p. 398-4050000, 2023
Part of EBioMedicine, 2023
Part of EBioMedicine, 2023
Part of Clinical Physiology and Functional Imaging, p. 120-127, 2023
Part of Alimentary Pharmacology and Therapeutics, p. 399-408, 2023
Federated analyses of multiple data sources in drug safety studies
Part of Pharmacoepidemiology and Drug Safety, p. 279-286, 2023
Part of Acta Paediatrica, p. 1011-1018, 2023
Part of Alimentary Pharmacology and Therapeutics, p. 475-485, 2023
Part of Diabetologia, p. 800-812, 2023
Part of American Journal of Gastroenterology, p. 511-522, 2023
- DOI for The Contribution of Genetic Risk and Lifestyle Factors in the Development of Adult-Onset Inflammatory Bowel Disease: A Prospective Cohort Study
- Download full text (pdf) of The Contribution of Genetic Risk and Lifestyle Factors in the Development of Adult-Onset Inflammatory Bowel Disease: A Prospective Cohort Study
Part of Cancer Epidemiology, Biomarkers and Prevention, p. 809-817, 2023
- DOI for Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis
- Download full text (pdf) of Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis
Physical Activity, Sedentary Behavior, and Type 2 Diabetes: Mendelian Randomization Analysis
Part of Journal of the Endocrine Society, 2023
Atopic dermatitis and chronic kidney disease: a bidirectional Mendelian randomization study
Part of Frontiers in Medicine, 2023
Ultra-processed food intake and incident venous thromboembolism risk: Prospective cohort study
Part of Clinical Nutrition, p. 1268-1275, 2023
Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
Part of Clinical Proteomics, 2023
Part of BMC Medicine, 2023
Part of Cancer Epidemiology, Biomarkers and Prevention, p. 1048-1060, 2023
Part of Diabetes Care, p. 828-835, 2023
Part of British Journal of Obstetrics and Gynecology, p. 891-901, 2023
- DOI for Pre-pregnancy participation and performance in world's largest cross-country ski race as a proxy for physical exercise and fitness, and perinatal outcomes: Prospective registry-based cohort study
- Download full text (pdf) of Pre-pregnancy participation and performance in world's largest cross-country ski race as a proxy for physical exercise and fitness, and perinatal outcomes: Prospective registry-based cohort study
Part of PLOS ONE, 2023
- DOI for Acute effects of nitrate and breakfast on working memory, cerebral blood flow, arterial stiffness, and psychological factors in adolescents: Study protocol for a randomised crossover trial
- Download full text (pdf) of Acute effects of nitrate and breakfast on working memory, cerebral blood flow, arterial stiffness, and psychological factors in adolescents: Study protocol for a randomised crossover trial
Epidemiology of sarcopenia: Prevalence, risk factors, and consequences
Part of Metabolism, 2023
Diet Quality and Risk of Older-onset Crohn's Disease and Ulcerative Colitis
Part of Journal of Crohn's & Colitis, p. 746-753, 2023
Part of Metabolism, 2023
- DOI for Renoprotective effects of genetically proxied fibroblast growth factor 21: Mendelian randomization, proteome-wide and metabolome-wide association study
- Download full text (pdf) of Renoprotective effects of genetically proxied fibroblast growth factor 21: Mendelian randomization, proteome-wide and metabolome-wide association study
Part of Journal of Crohn's & Colitis, p. 777-785, 2023
- DOI for Bidirectional Mendelian Randomisation Analysis Provides Evidence for the Causal Involvement of Dysregulation of CXCL9, CCL11 and CASP8 in the Pathogenesis of Ulcerative Colitis
- Download full text (pdf) of Bidirectional Mendelian Randomisation Analysis Provides Evidence for the Causal Involvement of Dysregulation of CXCL9, CCL11 and CASP8 in the Pathogenesis of Ulcerative Colitis
Intra‐individual stability of longitudinal urinary steroid profiles in Swedish athletes
Part of Drug Testing and Analysis, p. 769-778, 2023
Part of The journals of gerontology. Series A, Biological sciences and medical sciences, 2023
Swedish Snuff (Snus), Cigarette Smoking, and Risk of Type 2 Diabetes
Part of American Journal of Preventive Medicine, p. 60-66, 2023
Part of CELL REPORTS MEDICINE, 2023
- DOI for Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses
- Download full text (pdf) of Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses
The metabolomic profiling of total fat and fat distribution in a multi-cohort study of women and men
Part of Scientific Reports, 2023
Part of European Heart Journal - Quality of Care and Clinical Outcomes, 2023
Part of Genome Medicine, 2023
Part of American Journal of Hematology, 2023
Genetically predicted plasma cortisol and common chronic diseases: A Mendelian randomization study.
Part of Clinical Endocrinology, 2023
Part of medRxiv : the preprint server for health sciences, 2023
Part of Journal of the National Cancer Institute, 2023
Urinary phosphate is associated with cardiovascular disease incidence.
Part of Journal of Internal Medicine, p. 358-369, 2023
Part of Metabolism, p. 155555, 2023
Plasma protein and venous thromboembolism: prospective cohort and mendelian randomisation analyses.
Part of British Journal of Haematology, 2023