Microstructure-Property Relationships of Agglomerates Formed by Dry Granulation
Developing a formulation technology platform for rational design of the manufacturing properties of dry granulated particles.
Tid och finansiering
- Funder: Vinnova
Beskrivning
Research scientist: Maryam Tofiq, MSc
Principal Investigator: Professor Göran Alderborn, Department of Pharmaceutical Biosciences, Uppsala University
Scientific and industrial context. Agglomerates of different types are frequently used in solid formulation, including tablets and dry powder inhalers. Lately, the interest in using dry technologies for the formation of agglomerates has increased substantially, for example to be used in continuous manufacturing. The manufacturing properties of agglomerates are related to their microstructure and to their composition.
Aim. The aim of the project is to study the relationship between microstructure and the mechanical and functional properties of agglomerates formed by dry granulation and investigate the effect of composition on such microstructure-property relationships with a special focus on agglomerate plasticity. The aim is further to develop a procedure for the assessment of mechanical properties of agglomerates.
Outcome. A formulation technology platform for rational design of the manufacturing properties of dry granulated particles.